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Computer-Aided Detection (CAD) Miss of a Right Upper Lobe Lung Cancer

Imaging findings

A chest radiograph processed through a computer-aided detection (CAD) system flags three findings, none of which correspond to the actual abnormality; review of the original radiograph instead shows a subtle abnormal contour along the right superior mediastinal margin with fullness of the paratracheal stripe, which CT confirms represents a sizable right upper lobe cancer at the thoracic inlet.

Key takeaways

Over-reliance on CAD-flagged regions can cause a real finding outside those regions to be overlooked, particularly at the thoracic inlet near the first rib -- a location cancers characteristically hide -- reinforcing that images should be interpreted independently before reviewing CAD prompts.

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