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Pleomorphic Esophageal Lipoma

Pleomorphic Esophageal Lipoma▶ Watch on YouTube — age-restricted, cannot embed here

Imaging findings

Chest radiograph demonstrates a large, rounded retrocardiac mass outlined by a thin rim of esophageal air. Chest CT confirms a large, low-density intraluminal esophageal mass with predominant fat attenuation interspersed with heterogeneous soft tissue components, causing marked splaying and narrowing of the adjacent esophageal lumen.

Key takeaways

Pleomorphic lipoma of the esophagus is a rare, benign, slow-growing mesenchymal tumor that presents with progressive dysphagia. On histology, these tumors can be easily mistaken for liposarcomas, but they are characterized by the pathognomonic presence of floret-like giant cells with multinucleated, flower-petal-like nuclei.

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