CTICasesGemcitabine-Induced Organizing Pneumonia in a Prior Radiation Field
Imaging findings
In a patient previously treated with radiation for Hodgkin lymphoma who later developed recurrence treated with chemotherapy including gemcitabine, serial CTs after starting chemotherapy show new, vague, centrally distributed ground-glass opacity that progresses over two weeks, localized predominantly to the prior radiation treatment field rather than diffusely throughout the lungs.
Key takeaways
Gemcitabine is a radiomimetic chemotherapy agent capable of triggering recall pneumonitis/organizing pneumonia specifically within a previously irradiated lung field, so new ground-glass opacity that recapitulates an old radiation port after starting a radiomimetic drug should prompt consideration of a recall phenomenon rather than infection or tumor progression.
AI-assisted summary — may contain errors. Verify against the source video. Learn more
More from this webinar
- Superior Accessory FissureCongenital
- Incidentally Discovered Small ThymomaNeoplastic
- Disseminated Coccidioidomycosis with CNS Vasculitis and Necrotizing Lung DestructionInfection
- Cavitary Cryptococcal Pneumonia in Autoimmune Hepatitis with CirrhosisInfection
- Type 1 Truncus Arteriosus with Right Aortic ArchCongenital
- Unicuspid Aortic Valve with Mixed Stenosis and RegurgitationCongenital
- Recall Radiation Pneumonitis in a Previously Irradiated Breast FieldILD
- Second Case of Organizing Pneumonia in a Prior Spinal Radiation FieldILD
See all cases from July 12, 2018 →
Related ILD cases
- Minocycline-Induced Organizing Pneumonia
- Naltrexone (Vivitrol)-Induced Acute Eosinophilic Pneumonia
- Advanced Pulmonary Langerhans Cell Histiocytosis with an Unusual Vascular Finding
- Familial Pulmonary Fibrosis from Surfactant Protein C (SFTPC) Deficiency (Father and Infant Son)
- Familial Pulmonary Fibrosis from Surfactant Protein C Deficiency with Incidental Lung Adenocarcinoma in the Affected Parent
- Lymphoid Interstitial Pneumonia (LIP) in Sjogren Syndrome