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Sarcomatoid Mesothelioma with Osteoid Differentiation

Imaging findings

An older case showed a dense left-sided pleural mass with a small left lung on radiograph, and axial CT demonstrated a large, densely mineralized/osteoid mass with regions of very high attenuation, confirmed to be sarcomatoid mesothelioma with osteoid (bone) differentiation.

Key takeaways

Sarcomatoid mesothelioma can show osseous/osteoid differentiation producing markedly dense, bone-forming pleural tumor, echoing the calcifying sarcomatoid mesothelioma case shown earlier in the conference and reinforcing that heavy intratumoral mineralization is a recognized, if uncommon, feature of this subtype.

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