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Nodular Pulmonary Edema

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Imaging findings

Initial chest radiography and CT show bilateral, poorly-defined, ground-glass attenuation nodules with smooth interlobular septal thickening and a generous cardiovascular silhouette. Follow-up imaging obtained just two days later demonstrates near-complete resolution of the nodular opacities following aggressive diuresis.

Key takeaways

Pulmonary edema can rarely present in a highly atypical, nodular, or centrilobular distribution that mimics multifocal infection, transfusion reactions, or acute interstitial pneumonitis. A rapid response to diuresis (typically within 24 to 48 hours) is a key diagnostic feature of nodular pulmonary edema, which is often precipitated by acute renal failure or transient fluid overload in transplant patients.

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