CTICasesPrimary mediastinal CIC-rearranged sarcoma
Imaging findings
CT scan of a 43-year-old male shows a large, solid, homogeneous mediastinal mass centered in the subcarinal region, causing mass effect on the left atrium and pulmonary veins, with an associated pericardial effusion.
Key takeaways
CIC-rearranged sarcomas are highly aggressive, undifferentiated small round cell tumors (part of the Ewing sarcoma family) that rarely present as primary mediastinal masses. They typically demonstrate rapid progression, local invasion, and a poor prognosis.
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