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Intrapulmonary Solitary Fibrous Tumor with Cystic Changes

Intrapulmonary Solitary Fibrous Tumor with Cystic Changes▶ Watch on YouTube — age-restricted, cannot embed here

Imaging findings

Chest radiography and CT reveal a large, well-circumscribed, multi-septated cystic lesion in the left lower lobe containing significant central solid components and dense, coarse calcifications. Serial comparison over a five-year period shows that the mass is entirely stable in size and configuration. Histology of the resected specimen demonstrates an intrapulmonary solitary fibrous tumor of the pleura with benign features and cystic spaces lined by respiratory epithelium.

Key takeaways

Solitary fibrous tumors (SFTs) are mesenchymal neoplasms that typically originate in the pleura but can rarely present as primary intrapulmonary masses. Although SFTs are classically solid, they can undergo extensive cystic degeneration or entrap adjacent lung parenchyma and bronchi, creating a multi-septated, air-containing appearance that mimics congenital lesions like pulmonary sequestrations, congenital pulmonary airway malformations (CPAMs), or bronchogenic cysts.

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