CTICasesNodular Sarcoidosis Mimicking Ground-Glass Opacity
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Imaging findings
High-resolution chest CT shows diffuse, symmetric areas of apparent ground-glass opacity, primarily in a subpleural and bronchovascular distribution. On thin-section images, these regions are resolved as highly dense, fine granular networks of micro-nodules tracking along the major fissures, subpleural lung surfaces, and bronchovascular bundles.
Key takeaways
Sarcoidosis is a systemic granulomatous disease that classically presents with well-defined nodularity in a perilymphatic distribution. However, when the granulomatous nodules are extremely tiny and dense, they can coalesce and mimic ground-glass opacities on standard-resolution CT. Utilizing thin-section HRCT is critical to identify the underlying micro-nodular, granular nature of the process and differentiate it from interstitial lung diseases like non-specific interstitial pneumonia (NSIP) or hypersensitivity pneumonitis.
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