CTICasesLymphomatoid Granulomatosis (Grade 3)
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Imaging findings
Chest CT reveals multiple nodular opacities of varying sizes scattered throughout the lungs. Many of these lesions demonstrate central necrosis and cavitation, and the largest nodules are surrounded by ill-defined halos of ground-glass opacity. Mild mediastinal lymphadenopathy is also present.
Key takeaways
Lymphomatoid granulomatosis is an Epstein-Barr virus (EBV)-associated angiocentric and angiodestructive lymphoproliferative disorder. Its radiographic appearance closely mimics granulomatosis with polyangiitis (GPA) and necrotizing infections, typically presenting with multiple cavitating nodules. Histopathologic diagnosis is critical for differentiating grade 3 disease from other lymphomas and systemic vasculitides.
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