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Pulmonary Nocardiosis in a Stem Cell Transplant Recipient

Imaging findings

A stem cell transplant recipient with febrile neutropenia had a prior radiograph showing low lung volumes and mild atelectasis. CT later shows a new nodular consolidation in the right lung base with prominent air bronchograms. The lesion is hard to see on the radiograph because it sits behind the dome of the diaphragm.

Key takeaways

The presenter uses air bronchograms within a nodule as a soft argument against fungal infection, and here it turned out to be Nocardia. Nocardia nodules are often seen in the upper lungs in solid organ transplant recipients, but they also occur in the lower lobes. Trimethoprim-sulfamethoxazole prophylaxis after transplant usually prevents Nocardia, and it also covers Pneumocystis.

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