Pneumocystis jirovecii Pneumonia during Dapsone Prophylaxis
[...]. Pneumocystis jirovecii Pneumonia during Dapsone Prophylaxis. CTICases. Published October 1, 2026. https://cticases.com/c/ke6ab
Imaging findings
A clean CT in June is followed by a September radiograph with vague opacities, most noticeable in the right lung. CT confirms mild bilateral ground-glass opacity. A radiograph a few days later shows much denser bilateral opacities as the infection progressed.
Key takeaways
Patients with Pneumocystis pneumonia often have severe shortness of breath with relatively mild imaging changes. Pulmonary alveolar proteinosis is the opposite: it can look terrible on imaging with less dyspnea. This patient could not tolerate trimethoprim-sulfamethoxazole and was switched to dapsone, and Pneumocystis broke through. Both Pneumocystis and Nocardia are largely preventable with trimethoprim-sulfamethoxazole prophylaxis.
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