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Angioinvasive Cunninghamella (Mucormycosis) infection

Imaging findings

CT scan of a neutropenic patient shows multiple nodular opacities, including a dominant mass showing a reverse halo sign and an occluded feeding pulmonary artery branch. Lavage grew Cunninghamella.

Key takeaways

Cunninghamella is a genus within the Mucorales order. Angioinvasive mucormycosis classically presents with the reverse halo sign and arterial occlusion, representing hemorrhagic infarction, and is highly lethal in neutropenic patients.

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