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Blastomycosis Empyema

Imaging findings

Serial chest radiographs in an 8-year-old girl show progressive, unresolving right lobar consolidation that rapidly develops a large pleural effusion and right paratracheal lymphadenopathy. Chest CT demonstrates a complex, loculated right empyema with subpleural necrotizing pneumonia and a bronchopleural fistula, leading to persistent pneumothorax and subcutaneous emphysema despite tube thoracostomy.

Key takeaways

Although pleural effusion and bulky lymphadenopathy are classically associated with bacterial or histoplasmosis infections and are considered atypical for blastomycosis, blastomycosis can occasionally present as a severe, necrotizing pneumonia complicated by empyema and bronchopleural fistula, particularly in pediatric patients. DNA probe testing on bronchial washings or pleural fluid can aid in prompt diagnosis when standard cultures are negative.

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