CTICasesLymphoid Interstitial Pneumonia
Imaging findings
Chest CT in a patient with a background of Sjögren's syndrome shows widespread, bilateral, ill-defined low-attenuation ground-glass and solid consolidative nodules, predominantly peripheral. Pathological biopsy of a nodule confirms a polyclonal lymphoplasmacytic infiltrate without cytological atypia, and only a single isolated cyst is noted.
Key takeaways
Lymphoid interstitial pneumonia (LIP) is a benign lymphoproliferative disorder characterized by diffuse infiltration of the alveolar interstitium by lymphocytes and plasma cells. It is strongly associated with Sjögren's syndrome and other autoimmune disorders. While classically presenting with thin-walled cysts, LIP can also present as ground-glass opacities, consolidative nodules, and centrilobular nodularity, and responds well to steroid or rituximab therapy.
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