CTICasesNodular Lymphoid Hyperplasia in Common Variable Immunodeficiency
Imaging findings
Chest CT in a patient with common variable immunodeficiency (CVID) demonstrates widespread, diffuse bilateral pulmonary nodules and associated mediastinal and hilar lymphadenopathy. Splenomegaly is also present. Pathological biopsy confirms focal nodular lymphoid hyperplasia.
Key takeaways
Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder characterized by hypogammaglobulinemia. Patients frequently develop non-infectious, benign lymphoproliferative pulmonary diseases, including lymphoid interstitial pneumonia, follicular bronchiolitis, and nodular lymphoid hyperplasia. These lesions can mimic lymphoma or active infection on CT, requiring histological confirmation to rule out clonal malignancy.
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