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Desmoplastic Pleural Mesothelioma mimicking Empyema

Imaging findings

CT in a patient treated for a paramnemonic effusion/empyema shows progressive, lobulated, and circumferential pleural thickening and effusion, confirmed on biopsy as desmoplastic pleural mesothelioma.

Key takeaways

Desmoplastic pleural mesothelioma is a rare, fibrous variant of mesothelioma that can mimic chronic empyema or pleural sclerosis. Circumferential, nodular pleural thickening and involvement of the mediastinal pleura are key clues favoring malignancy.

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