CTICasesNUT Midline Carcinoma of the Mediastinum
Imaging findings
CT demonstrates a massive infiltrative mediastinal mass invading the left atrium and superior vena cava (causing hot quadrate liver sign), displaying squamous features on biopsy, representing NUT midline carcinoma.
Key takeaways
NUT midline carcinoma is a rare, highly aggressive subtype of poorly differentiated carcinoma defined by rearrangement of the NUT gene. It typically arises in midline structures (mediastinum, head/neck) of young patients and is frequently misdiagnosed as squamous cell or thymic carcinoma.
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