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Disseminated Coccidioidomycosis with ARDS

Imaging findings

Sequential chest radiographs and CT in a 23-week pregnant woman of Central American origin demonstrate progressively worsening bilateral miliary-to-confluent micronodular infiltrates, progressing to ARDS-like consolidation over two months, with coexisting skin ulcers. CT shows coalescent upper lobe predominant micronodules with developing traction bronchiectasis consistent with organizing phase of acute lung injury.

Key takeaways

Disseminated coccidioidomycosis is a potentially fatal complication of Coccidioides infection, occurring at a dramatically increased rate during pregnancy due to immunosuppression. It can present with miliary pulmonary nodules that coalesce and cause ARDS. The diagnosis should be strongly suspected in individuals from endemic regions (Southwest US, Central/South America) presenting with progressive respiratory failure, especially in pregnancy.

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