CTICasesNodular Lymphoid Hyperplasia of BALT (in CVID)
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Imaging findings
Chest radiograph shows patchy lung consolidation that worsened over years. Current CT reveals soft nodules and patches distributed throughout both lungs, which were also present as smaller versions on earlier scans. Mediastinal and hilar lymphadenopathy are also seen.
Key takeaways
This patient with common variable immunodeficiency (CVID) developed extensive pulmonary lymphoid infiltration. Biopsy revealed nodular lymphoid hyperplasia of the bronchus-associated lymphoid tissue (BALT), without evidence of a monoclonal population suggestive of lymphoma. This represents a severe form of lymphoid proliferation in the lung in the setting of immune dysregulation. The condition responded to corticosteroids, with bone marrow transplantation planned for immune system reconstitution.
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