CTICasesHypogammaglobulinemia with Bronchiectasis
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Imaging findings
A frontal chest x-ray showed thickened interstitial markings, possibly linear opacities, in a bronchovascular distribution, along with some tenting of the diaphragms and mild reticular opacities indicative of distal airway disease. The corresponding CT demonstrated classic findings of lower lobe predominant bronchiectasis, multifocal parenchymal and interface thickening from recurrent infections, airway-borne scarring, and some peribronchial cavities. Significant bronchiectasis was present, with some areas appearing finger-like and others more cystic, along with chronic mucus plugging.
Key takeaways
Hypogammaglobulinemia is associated with recurrent pulmonary infections, leading to chronic mucus plugging and progressive bronchiectasis, typically with a lower lobe predominance. Imaging findings reflect chronic airway inflammation and structural damage from repeated infections.
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