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Granulomatosis with Polyangiitis (GPA) with Alveolar Hemorrhage

Granulomatosis with Polyangiitis (GPA) with Alveolar Hemorrhage▶ Watch on YouTube — age-restricted, cannot embed here

Imaging findings

Radiograph showed multifocal consolidation. CT revealed areas of consolidation, air bronchograms, and large areas resembling 'reverse halos,' alongside some ground glass opacities. The patient had peripheral eosinophilia and a positive C-ANCA. A skin lesion biopsy was read as Wegener's (Granulomatosis with Polyangiitis).

Key takeaways

This case demonstrates Granulomatosis with Polyangiitis (GPA) presenting with a subacute course leading to alveolar hemorrhage. Imaging findings of consolidation with air bronchograms and reverse halos, coupled with peripheral eosinophilia and positive C-ANCA, are characteristic. Skin biopsy can also confirm the diagnosis.

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