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Pulmonary Veno-Occlusive Disease

Imaging findings

Non-contrast CT chest in a young patient with infantile-onset pulmonary hypertension shows a main pulmonary artery dilated to three times the size of the aorta. There is smooth interlobular septal thickening, a small left atrium, and marked amorphous mediastinal and hilar lymphadenopathy.

Key takeaways

PVOD presents with severe pulmonary hypertension. Key CT findings include smooth septal lines, ground-glass centrilobular nodules, and prominent mediastinal/hilar lymphadenopathy representing dilated lymphatics draining the congested lungs.

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