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Unicentric Hyaline Vascular Castleman Disease

Imaging findings

CT demonstrates a well-defined, incidental extrapulmonary mass near the internal mammary vessels, without FDG avidity on PET. The lesion is small and iso-attenuating, making the diagnosis elusive. Pathology confirmed unicentric hyaline vascular-type Castleman disease.

Key takeaways

Unicentric Castleman disease (UCD), particularly hyaline vascular type, typically presents as a solitary, well-circumscribed mediastinal, hilar, or extra-pleural mass. It can show moderate enhancement on CT due to rich vascularity, and is frequently mistaken for a solitary fibrous tumor, schwannoma, or lymph node metastasis. PET is typically low or negative. Surgical resection is curative.

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