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Diffuse Large B-Cell Lymphoma of the Lung and Pericardium

Imaging findings

Chest CT shows a large necrotizing mass in the left upper lobe with an air-fluid level and associated consolidation and collapse. There is contiguous soft tissue thickening of the pericardium with a pericardial effusion and a large mass encasing the coronary arteries without causing luminal collapse. A prior PET scan from months earlier demonstrated the necrotizing left upper lobe mass with a normal heart, indicating subsequent progression of the disease into the pericardium.

Key takeaways

Diffuse large B-cell lymphoma (DLBCL) can primarily involve the lung and dramatically extend along lymphatic pathways to encase the pericardium and epicardial structures. While pericardial encasement without coronary compression is highly suggestive of lymphoma, the atypical presentation of a necrotic pulmonary mass can initially mimic infectious disease or metastatic lung carcinoma.

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