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Sarcoidosis Presenting with Uveitis and a Miliary Nodular Pattern

Imaging findings

Chest radiograph and subsequent high-resolution CT in a patient presenting with uveitis reveal a highly abundant, fine nodular pattern. The nodules exhibit a perilymphatic distribution, clustered primarily along the minor and major fissures, with minimal involvement of the costal pleural surfaces, and show no evidence of air trapping on expiratory imaging.

Key takeaways

Sarcoidosis is a systemic granulomatous disease that commonly manifests in the eyes as uveitis, and screening chest radiographs are routinely performed in this clinical setting. On high-resolution CT, a "miliary" sarcoid pattern can mimic a random distribution but is differentiated by its underlying perilymphatic clustering, particularly along the fissures.

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