CTICasesMALT Lymphoma
Imaging findings
Chest radiographs and CT in a patient with Sjogren's syndrome show a progressive, solid nodular mass in the left lung apex. Background findings include numerous, thin-walled parenchymal lung cysts distributed predominantly in the lower lobes, consistent with lymphocytic interstitial pneumonia (LIP). Resection of the apical nodule confirms extranodal marginal zone B-cell lymphoma of bronchus-associated lymphoid tissue (MALT lymphoma).
Key takeaways
Sjogren's syndrome is strongly associated with benign and malignant lymphoproliferative disorders. Lymphocytic interstitial pneumonia (LIP) is a benign lymphoproliferative disease that typically presents with thin-walled lung cysts (hypothesized to relate to protein deposition or small airway obstruction). However, these patients have an increased risk of developing malignant B-cell lymphoma, most commonly MALT lymphoma, which presents as a progressive nodule, consolidation, or mass within the cystic lung parenchyma.
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