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Bubbly Lung Disease / Airspace Expansion with Fibiosis

Imaging findings

CT scans show rapidly progressive, giant cystic/bubbly lung spaces in the lower lobes over 18 months, associated with mild traction bronchiectasis and lung volume expansion rather than volume loss.

Key takeaways

Airspace expansion with fibrosis (AEF) or bubbly lung disease can mimic honeycombing but lacks a dense fibrotic matrix and results in lung expansion rather than volume loss. It can represent a form of emphysema with localized fibrosis.

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