CTICasesAlpha-1 Antitrypsin Deficiency
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Imaging findings
The imaging showed significant panlobular emphysema and cystic changes in the lung bases, accompanied by prominent cylindrical bronchiectasis. The pattern of lower-lobe predominant emphysema in a non-smoker is highly suggestive of alpha-1 antitrypsin deficiency.
Key takeaways
When bronchiectasis and lower-lobe predominant emphysema are seen, particularly in a non-smoker, alpha-1 antitrypsin deficiency is a crucial diagnosis to rule out.
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