CTICasesGranulomatous Lymphocytic Interstitial Lung Disease (GLILD) in Common Variable Immunodeficiency (CVID)
Imaging findings
High-resolution CT demonstrates bilateral, patchy ground-glass opacities, consolidated regions, and ill-defined small nodules with a mid-to-lower lung predominance, accompanied by mild mediastinal lymphadenopathy. Laboratory correlation shows profound hypogammaglobulinemia.
Key takeaways
Granulomatous lymphocytic interstitial lung disease (GLILD) is a severe, non-infectious, pulmonary manifestation of common variable immunodeficiency (CVID). It can mimic sarcoidosis, organizing pneumonia, or lymphoma. Diagnosing CVID-associated GLILD relies on identifying characteristic multi-focal nodular and consolidative patterns on CT combined with a clinical history of recurrent infections and laboratory evidence of severe hypogammaglobulinemia.
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