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Metastatic Pancreatic Adenocarcinoma with Peripheral Halo Sign

Imaging findings

Chest radiograph showed small lung volumes and ill-defined nodules. CT was striking for bilateral, basal-predominant ground-glass and part-solid nodules with prominent peripheral halo signs. Some nodules were quite large, while others were well-defined. Liver metastases were also noted.

Key takeaways

Metastatic pancreatic adenocarcinoma can present with a distinctive imaging pattern of pulmonary nodules exhibiting peripheral halo signs, which can sometimes appear confined by lobular anatomy with crazy paving. This appearance may be related to localized lipidic growth or mucin production, and such metastases can be highly vascular, occasionally causing hemoptysis.

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