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Iatrogenic Atrial Septal Defect (ASD) Post-Cryoablation

Iatrogenic Atrial Septal Defect (ASD) Post-Cryoablation▶ Watch on YouTube — age-restricted, cannot embed here

Imaging findings

A woman presented with platypnea-orthodeoxia (though suspected postural hypotension) after cryoablation for atrial fibrillation. CT to rule out pulmonary embolism showed a small, persistent atrial septal defect (ASD) of about 1 cm, later verified by echocardiography. This defect was created during the ablation procedure where the septum is intentionally perforated, but it failed to close spontaneously. The patient also has hypertensive cardiomyopathy with left ventricular diastolic dysfunction and left atrial enlargement.

Key takeaways

Ablation procedures for atrial fibrillation involve intentional perforation of the interatrial septum, typically at the fossa ovalis, to access the left atrium. While these defects usually close quickly, persistent iatrogenic ASDs can occur. In this case, with coexisting diastolic dysfunction, it led to left-to-right shunting, potentially contributing to postural hypotension. The defect will require percutaneous closure.

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