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Alveolar Septal Amyloidosis (TTR type)

Alveolar Septal Amyloidosis (TTR type)▶ Watch on YouTube — age-restricted, cannot embed here

Imaging findings

Parenchymal findings consisted of linear opacities, which had an appearance that was almost vascular or branched centrilobular, accompanied by ground-glass opacity.

Key takeaways

This case demonstrates the rare imaging manifestation of alveolar septal amyloidosis, specifically the TTR (transthyretin) type, in a patient who underwent heart transplantation for amyloidosis. While typically presenting as well-defined centrilobular lines, sometimes with calcification, this case showed a more linear and branchy pattern with ground glass, confirmed by biopsy. The pulmonary involvement can be indolent even post-transplant.

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