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Alveolar Septal Amyloidosis

Alveolar Septal Amyloidosis▶ Watch on YouTube — age-restricted, cannot embed here

Imaging findings

High-resolution CT shows slowly progressive, patchy ground-glass opacities, septal line thickening, and dense, consolidated airspace opacities predominantly in the lower lobes and the lingula.

Key takeaways

Alveolar septal amyloidosis is a rare, slowly progressive form of pulmonary amyloidosis associated with plasma cell dyscrasias. It presents with interstitial and septal thickening that can mimic lymphangitic carcinomatosis or lipidic-predominant adenocarcinoma, but can be distinguished by its slow progression and confirmation via lung biopsy showing amyloid deposition.

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