CTICasesGranulomatous-Lymphocytic Interstitial Lung Disease
Imaging findings
Chest CT in a patient with common variable immunodeficiency (CVID) demonstrates splenomegaly, lower mediastinal and chest wall lymphadenopathy, and diffuse, bilateral centrilobular and subpleural nodular opacities in a peri-lymphatic distribution, with severe coronary artery calcification.
Key takeaways
Granulomatous-lymphocytic interstitial lung disease (GLILD) is a rare, non-infectious pulmonary manifestation of CVID characterized by a combination of granulomatous and lymphoproliferative features. On CT, it mimics sarcoidosis, presenting with peri-lymphatic nodules, lymphadenopathy, and splenomegaly. It is treated with corticosteroids or immunosuppressants, and chronic inflammation may contribute to accelerated atherosclerosis.
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