CTICasesSenile (ATTR) Pulmonary Amyloidosis with Cystic Lung Disease
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Imaging findings
Chest radiograph and CT of an older woman with progressive shortness of breath showed basal-predominant calcified lung nodules, along with numerous irregular, thin-walled cystic airspaces (holes), also concentrated in the lung bases — an atypical distribution for centrilobular emphysema.
Key takeaways
Biopsy showed transthyretin (senile) amyloidosis without evidence of cardiac involvement. Basal-predominant calcified nodules with thin-walled cysts, in an older patient, should raise the possibility of amyloidosis, distinct from the typical distribution of emphysema.
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