CTICasesUncharacterized Pulmonary Amyloidosis with Cystic Lung Disease
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Imaging findings
CT of a woman with an abnormal chest radiograph showed a dense patch of lung behind the aorta and multiple thin-walled cystic airspaces (holes) in bilateral lung bases with some associated dense material. Biopsy confirmed amyloidosis.
Key takeaways
Immunohistochemistry showed positive kappa and lambda staining without clonality, and the amyloid subtype could not be classified as AA or AL (uncharacterized amyloid). Unlike the other two companion cases, this patient had no Sjögren syndrome or lymphoma, only a smoking history and prior suspected respiratory bronchiolitis — illustrating that the amyloid-cyst association can occur without a clear underlying lymphoproliferative or autoimmune driver.
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More from this webinar
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- Erdheim-Chester DiseaseNeoplastic
- Alveolar SarcoidosisAutoimmune
- Bony SarcoidosisAutoimmune
- Cardiac AmyloidosisMetabolic
- Senile (ATTR) Pulmonary Amyloidosis with Cystic Lung DiseaseMetabolic
- Pulmonary Amyloidosis with Cystic Lung Disease in Sjögren Syndrome and MALT LymphomaAutoimmune
- Left Main Coronary Artery AneurysmVascular
See all cases from June 27, 2014 →