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Nocardia Pneumonia in Kidney Transplant

Imaging findings

CT chest shows a solitary, large pulmonary nodule with air bronchograms in the left lower lobe, with associated small pleural effusion. The patient is a kidney transplant recipient recently taken off Bactrim prophylaxis, and BAL grew Nocardia.

Key takeaways

Nocardiosis is an opportunistic infection that classically presents as a solitary nodule or consolidation, often cavitating, in immunocompromised patients (such as transplant recipients). It frequently occurs after Bactrim (trimethoprim-sulfamethoxazole) prophylaxis is discontinued, which would otherwise cover Nocardia.

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