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Paecilomyces variotii Pulmonary Infection

Imaging findings

Chest CT shows a large, dense, nodular pulmonary consolidation surrounded by a prominent halo of ground-glass attenuation in the right lower lobe, resembling angioinvasive aspergillosis or mucormycosis. Sputum culture grew Paecilomyces variotii.

Key takeaways

Paecilomyces variotii is an opportunistic, thermophilic soil fungus that can cause invasive pulmonary disease in severely immunocompromised hosts. In patients on active voriconazole prophylaxis for aspergillosis, breakthrough fungal infections are typically caused by resistant species, including zygomycetes (Mucor) or rare opportunistic molds like Paecilomyces.

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