CTICasesAtezolizumab-Induced Organizing Pneumonia
Imaging findings
Follow-up chest CT scans show rapidly progressive, symmetric, ill-defined nodules with surrounding ground-glass halos, perilobular consolidations, and peri-bronchovascular opacities. A transbronchial biopsy confirmed organizing pneumonia, and follow-up imaging after steroid treatment showed significant improvement.
Key takeaways
Immune checkpoint inhibitors, such as atezolizumab, can cause drug-induced organizing pneumonia that can radiographically mimic metastatic disease or multi-focal infection. Because patients may remain asymptomatic or only mildly symptomatic despite extensive lung involvement, tissue sampling is often necessary to differentiate drug toxicity from tumor progression.
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