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Minimally Invasive Pulmonary Adenocarcinoma

Imaging findings

High-resolution CT shows a small, predominantly ground-glass nodule in the left lung apex with a tiny central solid component. Comparison between initial and follow-up CT scans demonstrates a subtle but definite increase in the size of the solid portion over several months. Histopathology confirmed a microinvasive adenocarcinoma of the lung.

Key takeaways

Part-solid nodules require careful, thin-section follow-up as the development or growth of a solid component is a strong indicator of invasive behavior in the adenocarcinoma spectrum. Under current classification systems, a microinvasive adenocarcinoma is characterized by a predominant lepidic growth pattern (ground-glass on CT) with an invasive focus (solid component on CT) measuring 5 mm or less in its largest dimension.

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