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Pulmonary MALT Lymphoma and LIP in Sjogren's Syndrome

Imaging findings

Serial chest CT scans over a 6-year period demonstrate multiple thin-walled, basal-predominant, perivascular lung cysts consistent with lymphocytic interstitial pneumonia (LIP) or light-chain deposition disease. In addition, there is a slowly growing, well-defined mass with air bronchograms and several solid nodules that have very gradually increased in size and cavitated, consistent with MALT lymphoma.

Key takeaways

Patients with Sjogren's syndrome are predisposed to lymphoproliferative disorders, including LIP and low-grade pulmonary MALT lymphoma. MALT lymphomas typically present as indolent, well-defined masses or consolidations with air bronchograms that can smolder over many years and may undergo cavitary change.

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