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Granulomatous-lymphocytic interstitial lung disease (GLILD) in CVID

Imaging findings

CT shows multifocal, irregular pulmonary masses and nodules in a patient with common variable immunodeficiency (CVID). Follow-up CT 2 months later shows spontaneous regression/waxing and waning of these lesions without treatment.

Key takeaways

GLILD is a rare non-infectious pulmonary manifestation of CVID. The lesions can show spontaneous waxing and waning, which can cause diagnostic confusion and concern for lymphoma or infection.

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