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Acute graft-versus-host disease

Imaging findings

Chest CT in an allogeneic stem cell transplant recipient shows a symmetric organizing pneumonia pattern with peribronchial consolidations, ground-glass opacities, and arcade-like subpleural bands, in the absence of active infection.

Key takeaways

While chronic graft-versus-host disease typically presents as bronchiolitis obliterans (air trapping), acute lung graft-versus-host disease can manifest as a sterile organizing pneumonia pattern. It must be differentiated from pulmonary infection and drug toxicity.

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