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Acromegaly-associated thymic hyperplasia

Imaging findings

Chest CT in a 37-year-old male post-pituitary surgery demonstrates symmetric enlargement of the thymus with preserved triangular shape and no focal mass effect, and brain MRI shows a pituitary macroadenoma in a patient with acromegaly.

Key takeaways

Growth hormone has a known stimulatory and growth-promoting effect on the thymus. Excess growth hormone secretion in adult patients with acromegaly can lead to thymic hyperplasia, which should not be mistaken for lymphoma or thymic malignancy.

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