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FDG-Labeled Pulmonary Embolus (Hot Clot)

Imaging findings

PET/CT demonstrates a focal, extremely intense area of FDG uptake (high SUV) in a branch of the pulmonary artery. A diagnostic contrast-enhanced chest CT performed at the same time shows no anatomic correlate, thrombus, or mass in that region.

Key takeaways

A 'hot clot' is a well-known nuclear medicine artifact that occurs during FDG injection when a small blood clot forms in the venous catheter, becomes highly labeled with the tracer, and subsequently embolizes to the pulmonary arterial bed. It presents as an intense, isolated focus of FDG uptake on PET without a corresponding lesion on CT.

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