CTICasesPost-Transplant Lymphoproliferative Disorder
Imaging findings
Chest radiograph and CT demonstrate a new, large, well-defined right lower lobe pulmonary mass and several smaller nodules scattered throughout both lungs. PET/CT shows intense FDG avidity in all nodules, with no significant mediastinal or hilar lymphadenopathy. Histopathology from a CT-guided biopsy confirms EBV-positive post-transplant lymphoproliferative disorder (PTLD) six years after transplantation.
Key takeaways
Post-transplant lymphoproliferative disorder (PTLD) is a spectrum of diseases ranging from benign polyclonal hyperplasia to malignant monoclonal lymphoma, occurring in immunosuppressed transplant recipients. It is frequently associated with Epstein-Barr virus (EBV) infection. In the lungs, it commonly presents as multiple nodules or masses, often without associated lymphadenopathy, and can occur many years after the transplant.
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