CTICasesCastleman Disease
Imaging findings
Chest and pelvic CT show multiple, avidly enhancing lymph nodes in the mediastinum, hila, and pelvis, accompanied by splenomegaly. The patient is a young, HIV-positive male.
Key takeaways
Multicentric Castleman disease is a rare lymphoproliferative disorder that is strongly associated with HIV and HHV-8 infection. The characteristic imaging findings include hypervascular, intensely enhancing lymphadenopathy and splenomegaly. It behaves like an aggressive lymphoma, requiring systemic chemotherapy or monoclonal antibody therapy.
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