CTICasesSTAT6-Positive Solitary Fibrous Tumor
Imaging findings
CT chest shows a large, hypervascular, pleural-based mass in the left hemithorax with internal areas of necrosis and calcification, displaying prominent collateral feeding vessels. Biopsy confirmed solitary fibrous tumor (SFT) with STAT6 immunohistochemical positivity.
Key takeaways
Solitary fibrous tumors of the pleura are mesenchymal neoplasms. While typically benign, they can show malignant features (necrosis, high mitotic activity). STAT6 nuclear expression is a highly specific immunohistochemical marker for SFT, resulting from the NAB2-STAT6 gene fusion.
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