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POEMS syndrome bone lesions

Imaging findings

Chest CT in a 31-year-old male with a right pleural effusion demonstrates multiple small, well-defined mixed osteosclerotic and osteolytic bone lesions resembling Cheerios with sclerotic rims and central lucency scattered throughout the spine, ribs, and scapula.

Key takeaways

POEMS syndrome is a rare multisystem disorder caused by an underlying clonal plasma cell proliferation. The characteristic bone lesions are small, mixed lytic and sclerotic lesions that are highly specific for this syndrome.

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