CTICasesProgression of NSIP to UIP-like Features in Sjogren's Syndrome
Imaging findings
Baseline CT (2014) showed a non-specific interstitial pneumonia (NSIP) pattern characterized by ground glass opacity, reticulation, peripheral and basal predominance with subpleural sparing, and traction bronchiectasis. Follow-up CT revealed progression with increased subpleural involvement and the development of honeycombing, taking on more UIP-like features, while still retaining some inconsistent elements like central involvement and patchy ground glass.
Key takeaways
This case emphasizes the progressive nature of interstitial lung disease in connective tissue diseases (here, Sjogren's syndrome, likely with overlap features), where NSIP can evolve over time to display fibrotic patterns resembling UIP, underscoring the value of longitudinal imaging comparison.
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